British Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation targeting an underground arms cache in Syria used by the IS group, per a report from the UK's MoD.
The site, located using reconnaissance, was thought to be housing weapons and explosive materials, the announcement noted, and was situated in mountainous terrain just north of the historic site of Palmyra in central Syria.
"Our fighter planes used precision-guided Paveway IV munitions to hit a number of access tunnels down to the site... early reports indicate the objective was successfully hit," the ministry announced.
There was no evidence of any harm to civilians in the strike on Saturday evening and every plane involved returned to base without incident, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as Daesh - established extremist governance over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action shows our UK leadership, and determination to work closely with allied nations, to eliminate any resurgence of the terrorist group and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the Defence Secretary stated.
RAF aircraft have carried out patrols over Syrian airspace to "forestall any efforts to regroup" of the group after its defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank every member of British forces participating in this mission for their professionalism and their valour," he added. "Including them were numerous British personnel deployed over the festive period. This action, to remove militants who pose a risk to our security, highlights how British military are prepared to act, continuously, keeping Britain secure within its borders and strong abroad."
Last December, the US military executed what it described as a "large-scale strike" targeting IS targets in Syria, subsequent to an ambush claimed the lives of two US troops and a civilian interpreter in Palmyra.
The UN reports Islamic State still boasts between 5,000 and 7,000 militants in Iraq and Syria.